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KMID : 0604519990250010120
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Journal of the Society of Cosmetic Scientists of Korea
1999 Volume.25 No. 1 p.120 ~ p.136
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Improvement in availability and stability of LG 106W by inclusion with β-cyclodextrin and its derivatives
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1이천구/1Cheon-Koo Lee
1조완구/1강세훈/2정성훈/1Wan-Goo Cho/1Seh-Hoon Kang/2Seoung-Hoon Jeong
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Abstract
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A newly synthesized polyhydroxy aromatic compound(LG 106W) has good skin
lightening effect. Inclusion complexation of LG 106W with β-cyclodextrin and its
hydroxypropyl and dimethyl derivatives was studied by the solubility method, scanning
elecron microscopy and differential thermal analysis. A relationship between host and
guest was clearly reflected in the magnitude of the stability constant(DM-β> HP-β>b
i-cyclodextrin). Formulation problems, which resulted from its very low solubility in
aqueous solution, were resolved by the inclusion formation. LG 106W from inclusions is
much more water-soluble than pure one. The improvement of pH and temperature
stability correlated with the increased solubility was also observed. Inclusion complex of
LG 106W had similar activity to pure LG 106W on the inhibition of melanin synthesis in
B-16 melanoma cell but showed lower irritation on cultured cell test in vitro. According
to the results, cyclodextrins might be one of the reliable candidates for improving the
availability of LG 106W.
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